study of renal glomerular mesangium and volume changes in alloxan induced diabetic rat

introduction: kidney is one of the target organs in diabetes mellitus. diabetic nephropathy is a major cause of end stage-renal disease and resulting an increased in morbidity and mortality of effected individuals. since diabetes is a progressive disease, therefore early diagnosis leads to better treatment. in this study primary diagnostic parameters were the goal. materials and methods: in this study morphometrical and stereological methods and stains of h&e; and pas were applied. experimental rats were classified in to two groups, 8 and 17 weeks after treatment, the animals with alloxan. results: 17 weeks diabetic rats showed increased in glomerular measangium and glomerular volume. conclusion: therefor this study showed that glomerular changes happen in earlier time can be an early diagnosis method in affected kidney.